Medicine is used to treat hypoactive sexual desire disorder in women.
Packet of medicine Addyi (flibanserin) tablets 100 mg
Mechanism of action (MOA)
Flibanserin acts as a full agonist of the 5-Ht 1A receptor, it activates the 5-Ht 1A and has been found to increase nor-epinephrine and dopamine levels and reduces the serotonin levels. For a normal sexual response it is necessary for these hormones to be balanced. Flibanserine usually improves the balance between these hormones and increases the sexual response.
Uses of Addyi
The main use of Addyi is to increase sexual response in women who have been suffering from hypoactive sexual desire disorder (HSDD) who have not gone through menopause. It is not for those who have gone through menopause or for those who just want to increase their sexual drive. It is also not for those who have decrease sexual drive because of some medical or mood disorder.
Dosage and Administration
Addyi comes in a tablet form. Take 1 tablet at bedtime. The tablet should be taken just before bed time and not any other time because it can increase blood pressure otherwise. Do not eat grapefruit while taking this medicine because grapefruit may interfere with its mechanism. If it does not work even after regular usage for 8 weeks please consult your doctor.
Side-Effects of Addyi
- Trouble sleeping
- Allergic reaction
- Swelling of tongue
- Swelling of throat
- Swelling of face
Do not take alcohol while taking this medicine as it results in low blood pressure. Even a glass of wine can be harmful.
Precaution and Warning
Before taking this drug please mention your full personal and family history to your doctor. As sometimes it can cause allergic reaction because of its inactive ingredients. Please mention any allergy or history of any other medical problems like liver disorders.
Avoid use of alcohol as it can cause low blood pressure. Before discontinuing the medicine ask your doctor about the procedure, do not discontinue abruptly.
Pregnancy and Breast-Feeding
If it is absolutely necessary then only you can use this medicine while pregnant but please clear its risk and effects with your doctor before taking.
It is not known that Addyi can mix into the breast milk therefore it is not confirmed if it can affect the infant or not therefore please consult your doctor or do not consume.
See also: Is Addyi Appropriate for Pregnant Women?
Some drugs may change the course of Flibanserine in the body. Drugs like azole antifungals like ketoconazole, fluconazole, certain calcium channel blockers like verapamil, diltiazem, macrolide antibiotics like clarithromycin, erythromycin and drugs that use to treat seizures like phenytoin and phenobarbitol and carbamazepine among others. Without doctor’s approval do not change the dosage and course of tablets.
Is Addyi Appropriate for Pregnant Women?
Addyi is exclusively used for men to treat and right a sexual shortcoming, for instance, erectile dysfunctions, BPH and distinctive sorts of sexual afflictions. Men tend to fulfill an erection when the brain stimulates the improvement of a compound known as nitric oxide. This nitric oxide tends to loosen up the nerves and empowers an improved measure of blood to stream in the veins of the penis. The sexual want in men is overall, more unconstrained and more physical. This is the sole reason in view of which men can achieve an erection so quickly along these lines adequately, even at the tiniest considered a sexual stimulant. In any case, in ladies, the sexual want is more mental and it is a direct result of this reason the women can value sexual pleasure with insignificant thoughts. On account of this wonder, women put aside an extended time of chance to react to sexual jars and this construes Addyi won't be unreasonably helpful for women.
There were definitely no signs and indications of developing life harmfulness, teratogenicity, or fetal poisonous quality recognized in pregnant mice or rats over the traverse of organogenesis, at up to 7 times the communicated human measurements (MRHD) of 40 mg/day. In a pre-birth and postnatal progress mull over in rats, postnatal pup survival decreased after maternal prologue to boundless Addyi doses higher than 5 times the MRHD. Signs of maternal hurtfulness happened at estimations higher than 8 times the MRHD. The surviving family had standard development and conceptive execution. Regardless, the analysts and researchers have not discovered any data related to the pregnancy in people. The pharmaceuticals which have been eaten up by a few women who are fit the bill to hold up under adolescents and pregnant women were checked and kept under strict watchfulness to perceive any kind of genuine results for the infant. Research on the lab animals did not clarify and give any sort of verification with respect to an enlivened occasion of the fetal issue. Appraisals on animal expansion structures have not had the ability to show a threat to the beginning life form and there hasn't been any sort of attractive and all around checked reviews in pregnant ladies.
This pharmaceutical and its metabolites evidently were released in the deplete of lactating rats at a couple of centers up to 2.4-overlay more noticeable than the maximal and the most imperative maternal plasma obsession. In any case, a peril to the breastfed youth can't be isolated completely. Regardless, the truth remains that there is no known human data on the release of this solution to the breastfed or into the chest deplete.
This pharmaceutical is not proposed or appeared for use in women by any methods or potential outcomes.
Following are some of the regulations which are followed in some of the leading nations regarding the use of Addyi for pregnant women:
United Kingdom: Use should be completely avoided.
Australia and the United States of America: Caution is very exhorted.
Sexual Disorders among Females and their Cure
If statistics were to be believed, the one disease which is grappling the entire population of the universe very slowly and calmly is the sexual disorder. It has become so serious that the reputed organisation of Institute of Mental and Psychological Disorders have even claimed that among all other factors which lead to psychological trauma among the general population, sexual failures are the prime among them all. Not only male, these sexually dysfunctions affect both the male and well as the females.
Now, the question arises that what is sexual dysfunction? Basically, sexual dysfunction is a collection of a whole range of diseases which are concerned with the inability of a person to function properly during his sexual activities. Be it erectile dysfunction, lack of sexual libido or premature ejaculation, each one of them can be summed up as erectile issues or sexual disorders.
However, according to latest studies, sexual disorders now include even more diseases which consist of a wide range of problems, both psychological as well as physical. Perhaps, the inability to reach to an orgasm for both men and women is the most serious issue which have been unearthed by the scientists recently.
Now, it is a very uncommon fact that the sexual disorders are mainly caused due to various social, mental, psychological as well as emotional issues. It is very often thought that all the sexual disorders are caused due to an improper lifestyle and a growing age. Although it is a correct assumption, yet, the mental factors play an equally critical role as compared to that of the physical factors.
Now, let us focus on the sexual issues which are generally faced by the women population. Even in the United States of America alone, 40 percent of the total female population are suffering from some kind of sexual disorders. This number is more horrific considering the fact that it has been taken from one of the most renowned research houses in the united States. Be it lack of libido, inability to get an excitement during sex or lack of lubrication in their vaginal walls; the women are slowly coming under the dangerous grip of the modern day’s newest cancer.
Be that as it may, in spite of the fact that it is exceptionally grisly that such a vast lump of the populaces has turned into the casualty of such a ceaseless malady, yet, what stresses the specialists the most is that 15 percent of such countless have expressed that these sexual issue have come up because of different anxieties and mental angles.
Be that as it may, different medicines and analysis techniques have additionally come up which concentrate primarily on females and their particular digestion.
All in all, now an inquiry emerges that what are the particular treatment methods which can be received to treat the ladies, remembering their particular digestion?
All things considered, despite the fact that there are different treatment strategies accessible which assert that they can cure sexual impotencies in ladies, we will be focussing essentially on the PDE inhibitors.
Like the male partners, female Cialis goes in to the digestion of the ladies and because of the nearness of the PDE inhibitors aggravates, the blood stream gets expanded to the clitoral and also the vaginal area, which takes increasingly measure of oxygen to the private parts and in this manner give an upgraded sexual want among the ladies.