Medicine are indicated for the treatment abnormal uterine bleeding in women. Usually Cycrin is given in those conditions when the body is not able to make enough of progestin.

Cycrin tablets

Packet of medicine Cycrin (medroxyprogesterone) tablets 10 mg

Composition of Cycrin

Medoxyprogesterone is a progesterone derivative which is odorless, white, powdery crystal. It is soluble in dioxane and acetone, freely soluble in CHCl3 (chloroform), sparingly soluble in methanol and insoluble in water. The inactive components of cycrin are: magnesium stearate, lactose, microcrystalline cellulose and methylcellulose.


This drug has many uses. In non-pregnant females who have not experienced menopause, cycrin is used to cure unusual uterine bleeding and in amenorrheic females it is used to restore the regular menstrual cycle. To decrease some severe menstrual symptoms like hot flashes, cycrin is used in the form of combined hormone replacement treatment. To reduce the risk of uterine cancer it is combined with estrogen for the replacement theory.

How to use Cycrin

This drug has to be taken orally as instructed by the doctor. For estrogen replacement treatment, take cycrin generally once in a day for the time duration prescribed by the physician. To cure amenorrhea and unusual uterine bleeding, the drug should be taken 1 in a day for 5 to 10 days usually. After discontinuing this drug, withdrawal bleeding occurs usually within 3 to 7 days.


Bloating, headache, nausea, breast tenderness, variation in vaginal secretion, blurred vision, mood swings, drowsiness, weight loss/gain or dizziness are the most common side-effects of cycrin. Consult the pharmacist/doctor promptly if serious side-effects like those mentioned below are observed:

  • Micturition
  • Abnormal bleeding in vagina
  • Melasma – dark patches on face/skin
  • Mood/mental changes
  • Changes in secretions of cervix
  • Edema
  • Pyrexia
  • Breast lumps
  • Fatigue
  • Yellowing skin/eyes
  • Blood clots
  • Abrupt vision changes
  • Confusion
  • Sudden headache
  • Fainting
  • Severe dizziness
  • Trouble breathing
  • Weakness/swelling/redness/pain in legs or arms
  • Swollen/painful calf muscles
  • Serious allergies
  • Loss of scalp hair


Inform about any allergies to medoxyprogesterone to the doctor. This drug should not be consumed if you are suffering from certain medical disorders like. The doctor should know about the past medical conditions like: blood clots, bleeding in brain, breast cancer, liver disorder, vaginal bleeding (undiagnosed), missed abortion, recent heart attack or stroke, thromboembolic diseases, thrombophlebitis, kidney problems, heart disease, breast lumps, hypertension, high cholesterol/triglyceride level in blood or diabetes. Smoking is strictly prohibited during the intake of this medicine as the smoke combined with cycrin increases the chances of hypertension, strokes, heart attacks and blood clots. Sunlight may be dangerous as this drug causes dark patches on the skin.

Cycrin in Pregnancy

Cycrin is not recommended during pregnancy as it may cause problem to the fetus mainly during the first trimester. This drug is excreted into the mother’s milk. Therefore before breast-feeding, consult your pharmacist/doctor.

What is Abnormal Vaginal Bleeding?

When a woman witnesses bleeding in between her periods, it is known to be abnormal vaginal bleeding. Other names used for the same conditions are metrorrhagia, spotting, or intermenstrual bleeding. Such abnormal bleeding is triggered by many different causes.

Some of the reasons that cause this condition can be easily treated. But, some may indicate that there is a more serious underlying condition which needs immediate attention. When you notice spotting or blood leaking in between periods, it is very crucial to see a doctor so that you can be tested, diagnosed, and treated for the same. Some of the potential causes that may lead to vaginal bleeding include:

  • Changes in medication
  • Stress
  • Cancer
  • Growth in the cervix or uterus
  • Hormonal imbalance
  • Vaginal dryness
  • Miscarriage

It is not normal to bleed in between your menstrual dates. Your menstrual cycle is supposed to last for about 21-35 days. Your menstrual bleeding can sometimes extend for a week. But, if the bleeding takes places anytime other than when it is considered normal, it can be triggered by the different factors mentioned above. We will discuss some of the causes in detail below.

Hormonal Imbalance

Two prominent hormones that are responsible for regulating our menstrual cycle are progesterone and estrogen. If any of the hormones go out of balance, they can result in spotting. Some factors that may trigger hormonal imbalance are:

  • Stopping or starting the use of birth control pills
  • Dysfunctional ovaries
  • Thyroid gland problems

Note that some women experience spotting when ovulating because of the hormonal changes. When you start taking any form of hormonal contraceptive, it is common to experience abnormal bleeding in the first three months. The contraceptives mentioned by the National Health Service of UK are:

  • Contraceptive injection or implant
  • Intrauterine device
  • Birth control pills
  • Contraceptive patch

Pregnancy Complications

Experiencing any complication when you are pregnant can lead to spotting. It can either be ectopic pregnancy or a miscarriage that can lead to abnormal bleeding. When the fertilized egg gets implanted in the fallopian tube instead of the uterus, it is known as an ectopic pregnancy.

Spotting may not always mean that there is a miscarriage. Though, it is important to consult your doctor immediately.


Abnormal vaginal bleeding may result from an infection in the reproductive organs. Some of the causes are:

  • Intercourse
  • Vaginal douching
  • Pelvic inflammatory disease
  • Sexually transmitted infection

Uterine Fibroids

These are noncancerous growths that originate in the uterus. It is common among women who have given birth.


Abnormal vaginal bleeding may also result due to cancer. Some of the organs that can result in bleeding are:

  • Ovaries
  • Cervix
  • Uterus
  • Vagina

Other Causes

Some of the causes that are rare, but can cause vaginal bleeding are:

  • Significant weight loss or gain
  • Extreme stress
  • Thyroid disorders
  • Inserting objects in the vagina
  • Diabetes

It is very important to seek medical attention if you are experiencing vaginal bleeding. In case, you are pregnant, it is important for you to know the cause behind the vaginal bleeding.